This project deals with the problem of administrative overload in managing students, faculty; support personnel, and course data in the University, taking a case study of the University of Uyo, AKS, Nigeria. It proposes a Secure Student Information System (SSIS). This is expected to be a secure web-based data management system as a solution. Having this goal in mind, object-oriented design, client-server architectures, server-side application development tools, and database technologies are explored. Security measures are designed where necessary on the system to prevent unauthorized access and the best configuration of these tools is selected. These application development tools will be mainly open source software ¿ where the user can have access to and modify the source code. As a result of the study, PHP (Hypertext Preprocessor) and Apache server pages are found as the optimal servers side programming tools for the application. A working prototype of the system is provided based on MySQL DBMS, Apache web server, and PHP server pages.