Agile methodologies have gained much popularity, as they are a good solution for short-term projects, this proposed methodological guide bases its focus on increasing project productivity and ensuring the quality of applications for mobile devices, aims to encourage the implementation of methodologies and development techniques, to identify needs and requirements in depth, provide appropriate software engineering elements for development and supported by agile methodologies.The methodological guide is divided into three (3) chapters, chapter 1 presents a conceptualization of the subject to be addressed and the theoretical basis for the correct application of the methodological guide as well as a brief description of the agile methodologies on which the proposed methodology is based, chapter 2 details the AEGIS-MD methodology, definition, approach, principles, practices and tools to be used by developers of mobile applications, at the end of the document are some recommendations, glossary and bibliographic references and formats for the stages.