This Book in the field of Alternative Methods in Organic Synthesis, involved (13) chapters in essential subjects information represented by: Chapter One: Selective Reaction, Alternative Methods for Synthesis via Selective Reaction, Selective Positions (Active Sites), Regioselective to formation cyclic compounds, Robinson Reaction, Claisen Condensation, Michael Additions, Types of Intra Molecular Reactions. Chapter Two: Three Components Reactions, Mechanism of Mannich reaction (Enamine). Chapter Three: Imine compounds, Mechanism (Formation of Imine group), Applications., Chapter Four: Chalcone- Aldole Reaction, Methods of Preparation, Cyclization of Chalcone, Chapter Five: Azo compounds, Reactions (Classic Reactions), and Novel reactions (Sulfazane, formazane, Cyclization), Formazane, Preparation, Sulfazane, Cyclization Reaction of Azo Group, Preparation. Chapter Six: Thiadiazole, General Methods of Preparation, Reactions (Classic Reactions, and Novel reactions). Chapter Seven: Oxadiazole, General Methods of Preparation. Chapter Eight: Triazole & Tetrazole, General Methods of Preparation. Chapter Nine: Thiazole, General Methods of Preparation. Chapter Ten: Antipyrine, General Methods of Preparation. Chapter Eleven: Lactam, Classifications of Lactams, General Methods of Preparation. Chapter Twelve: Isatin (Preparation, Reactions, Applications). Chapter Thirteen: The effect of Reaction conditions & Catalysis on The Products, Catalysis of Reduction and Oxidation for Carbonyl Compounds, Catalysis of Reduction & Oxidation for Nitro and Sulfur Compounds, Reactions of Grignard Reagent, Protecting Groups.