Tuberculosis (TB), a highly contagious lung disease, is the leading cause of worldwide death followed by malaria and HIV/AIDS. The World Health Organization (World Health Organization, 2018) alludes that more than 95% of TB patients live in developing countries that lack adequate healthcare funding and supporting medical infrastructure. This book discusses the challenges of the Tuberculosis Detection system in practical environments. This book provides some solutions to the problems associated with Automatic Tuberculosis Detection. Here a novel system for Automatic Tuberculosis Detection is designed and discussed.