Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Irreversible cessation of all brain activity, lack of eye movement, absence of respiratory reflexes and no response to pain are the main signs of brain death. Brain death was first described in 1959 by French neurophysiologists Mollaret and Goulon, raising ethical issues and making scientists redefine the criteria of death. Learn more about brain death, diagnostic criteria and the controversy surrounding the morality of organ donation in this book.