Speaker of the House of Representatives Gianni Simonelli is a second-generation New York Italian-American hell-bent on not being associated with the Mafia. The problem is that his brother is a member of a New York crime family. When the newly-elected President of the United States steps up to the podium to address the nation at his inauguration, the Secret Service agent assigned to protect him fires two bullets into the President's head, killing him. Reeling from the assassination, Gianni is called upon to help stabilize the administration.

Someone identified as 'the Emperor' leads a domestic terror organization known as VIPER, which has infiltrated America's national security agencies to gain control of its military power and wealth. Having evidence that the Secret Service and FBI may be a part of VIPER, Gianni turns to CIA Director Jill Shelton to find out who's behind the insurrection. As events spiral out of control, Gianni is left with no alternative but to seek help from his estranged brother, Mario. When the Mafia strikes VIPER in a brutal-but-effective way to help save the democracy from being overthrown, Gianni and Shelton face the real possibility that collaborating with the Mafia could result in them becoming crime family puppets.

Brothers is a modern-day story of Cain and Abel that asks the question, "Am I my brother's keeper?" The answer depends on which brother is asking the question, and the women that they encounter.