Cell Line Development -
-40% koodiga BOOKS
Saadetis 22-28 tööpäeva jooksul
30-päevane tagastamisõigus
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essent ... Täielik kirjeldus
Võib-olla meeldib sulle ka
TOP
The Myth of Normal: Trauma, Illness, and Healing in a Toxic Culture
-40% koodiga BOOKS
Laos
TOP
No Bad Parts: Healing Trauma and Restoring Wholeness with the Internal Family Systems Model
-40% koodiga BOOKS
Meie tarnija laos
TOP
Maybe You Should Talk to Someone: a therapist, her thearapist, and our lives revealed
-40% koodiga BOOKS
Meie tarnija laos
TOP
Aids to the Examination of the Peripheral Nervous System
-40% koodiga BOOKS
Meie tarnija laos
TOP
Harrison's Principles of Internal Medicine (Vol.1 & Vol.2)
Stephen Hauser, Joseph Loscalzo, Steven Holland, Dan Longo, J. Larry Jameson, Dennis Kasper, Carol Langford, Anthony Fauci
-40% koodiga BOOKS
Meie tarnija laos
TOP
The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma
-40% koodiga BOOKS
Meie tarnija laos
TOP
The Checklist Manifesto: How to Get Things Right
-40% koodiga BOOKS
Meie tarnija laos
TOP
How Not To Die: Discover the foods scientifically proven to prevent and reverse disease
-40% koodiga BOOKS
Meie tarnija laos
TOP
Lifespan: Why We Age - and Why We Don't Have To
-40% koodiga BOOKS
Meie tarnija laos
TOP
Vademecum Metabolicum: Diagnosis and Treatment of Inborn Errors of Metabolism Forword by William L. Nyhan, San Diego, USA
Johannes Zschocke, Georg F. Hoffmann
-40% koodiga BOOKS
Meie tarnija laos
TOP
ROAR: How to Match Your Food and Fitness to Your Unique Female Physiology for Optimum Performance, Great Health, and a Strong, Lean Body for Life
-40% koodiga BOOKS
Meie tarnija laos
TOP
Cellular and Molecular Immunology
Sarah Henrickson, Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai
-40% koodiga BOOKS
Meie tarnija laos
TOP
The Autistic Burnout Workbook: Your Guide to Your Personal Recovery Plan
-40% koodiga BOOKS
Meie tarnija laos
TOP
McGee's Evidence-Based Physical Diagnosis
-40% koodiga BOOKS
Meie tarnija laos
TOP
Physics, Pharmacology and Physiology for Anaesthetists: Key Concepts for the FRCA
Matthew E. Cross, Emma V. E. Plunkett
-40% koodiga BOOKS
Meie tarnija laos
TOP
Oxford Handbook of Clinical Medicine
Peter Hateley, Iain McGurgan, Ian B. Wilkinson, Tim Raine, Dearbhla Kelly, Kate Wiles
-40% koodiga BOOKS
Meie tarnija laos
TOP
Pocket Guide to Teaching for Clinical Instructors
-40% koodiga BOOKS
Meie tarnija laos
TOP
Oxford Handbook of Critical Care
Andrew Webb, Mervyn Singer, Alice Carter
-40% koodiga BOOKS
Meie tarnija laos
Kirjeldus
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms.
This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.
Lisateave
| Kirjastaja | Springer |
|---|---|
| Väljalaskeaasta | 2009 |
| Kaanetüüp | Kõvakaaneline |
| EAN | 9789048122448 |