Good Laboratory Practice (GLP) Handbook is designed to promote laboratories to GLP rules and knowledge. It has been proceeded as part of a technology transfer. The handbook is produced as an initiative of the laboratories on GLP issues, which comprised independent scientific specialists from around the world. This handbook will provide laboratories and trainers with the necessary technical aid for implementing GLP programmers as well as GLP Training manuals for trainers and trainees. The handbook comprises four parts, all updated, including: 1) explanation of the fundamentals of GLP; 2) support for GLP training; 3) methodology for GLP implementation in DEC research institutions; 4) GLP principles and guidance produced by the Organization of Economic Co-operation and Development (OECD), and reproduced here with OECD permission and particularly in the creation of a section on ¿stepwise¿ implementation of GLP, identifying clear milestones for the process. The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of of study types.