The manual outlines the basic concepts of immunology. Reflected information about the organs of the immune system and types of immunity, factors of innate and adaptive immunity, forms of immune response. Modern ideas about the causes of development and pathogenesis of the main immune disorders are covered in detail: immunodeficiency, autoimmune, allergic. Mastering the material presented in the manual allows you to form the skills to assess the immune status of a person necessary for diagnosing immune disorders, as well as the skills to correct the main disorders of the immune system and provide first aid in emergency conditions. The manual reflects modern ideas about immunorehabilitation, prevention of immunodeficiency, autoimmune and allergic diseases, gives modern ideas about the patterns of formation of anti-infective immunity, including post-vaccination.