Industrial systems engineering is a specialized branch of engineering, which is concerned with the optimization of complex processes, systems and organizations to achieve an effective utilization of time, human resources and material resources. The various fields of study inherent to this discipline are manufacture engineering, engineering management, process engineering, systems engineering, software engineering, etc. Modern industrial systems engineering uses computer simulation and mathematical optimization for the in-depth study of organizational and industrial systems as well as for systems analysis, evaluation and optimization. Besides these, the tools of data science and machine learning are also of importance in the study of systems. The applications of this field are diverse. It is used in flow process charting, strategizing for operational logistics, developing a new algorithm in a financial process, supply chain management, etc. This book elucidates the key aspects of the field of industrial and systems engineering and presents the technological advances in a comprehensive way. It unfolds the innovative aspects of industrial engineering which will be crucial for the progress of this field in the future. It strives to be a complete reference guide for students and experts working in this domain.