The members of two dysfunctional criminal organizations operating on either side of the Mississippi River at St. Louis become trapped by fate between outcast FBI agents and a local militia group. Mix in a daring, yet largely involuntary, escape orchestrated by two competing Colombian drug cartels, an introverted accountant, his floozy girlfriend who has a serious drinking problem, one mysterious helicopter pilot, the leader of a large Baptist church, several unsuspecting federal prisoners, and a disabled former FBI agent and all hell breaks loose in the shadow of the Gateway Arch.