Intro -- Parathyroid Hormone -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Structural pharmacology of PTH and PTHrP -- 1. Evolutionary biology of PTH and PTHrP -- 2. PTH mutations -- 3. PTHrP mutations -- 4. PTH and PTHrP pharmacology -- 4.1. PTH and PTHrP action is not identical -- 4.2. PTH and PTHrP signaling -- 4.3. PTH and PTHrP peptides providing insight into physiology -- Acknowledgments -- References -- Chapter Two: Salt inducible kinases and PTH1R action -- 1. Parathyroid hormone and PTH1R biology -- 2. PTH as anabolic therapies for osteoporosis -- 3. PTH action in osteocytes -- 4. Salt inducible kinases -- 5. Role of salt inducible kinases in responses to PTH in bone -- 6. Role of salt inducible kinases in responses to PTH in cartilage -- 7. Do salt inducible kinases participate in the renal actions of PTH? -- 8. PTH stimulates Cyp27b1 expression -- 9. PTH decreases phosphate reabsorption in proximal tubule -- 10. PTH increases calcium reabsorption in distal tubule -- 11. Summary and future directions -- References -- Chapter Three: Physiological regulation of phosphate homeostasis -- 1. Introduction -- 2. An overview of phosphate homeostasis -- 3. Intestinal phosphate absorption -- 4. Transcellular intestinal phosphate absorption and the role of NaPi-IIb -- 4.1. Other sodium-dependent transporters involved in transcellular phosphate absorption -- 4.2. Endocrine control of transcellular phosphate absorption -- 4.3. Paracellular intestinal phosphate absorption -- 4.4. Characterization and regulation of the paracellular pathway -- 5. Renal phosphate reabsorption -- 5.1. Regulation of renal phosphate reabsorption -- 6. Phosphate imbalance -- 6.1. Targeting renal phosphate transport -- 6.2. Targeting intestinal phosphate transport -- Conflict of interest -- References.