This collection reflects key milestones in research, addressing fundamental theories, emerging trends, and real-world applications of two closely connected disciplines of computer science: semantic computing and artificial intelligence (AI). The rapid evolution of computing has led to transformative advancements in semantic computing and AI simultaneously. Both fields have driven innovation in data processing, knowledge representation, and intelligent decision-making. This book presents a carefully curated selection of articles from the International Journal of Semantic Computing (IJSC), spanning from 2007 to 2025, capturing the journey in which the two disciplines became more and more connected, while expanding our understanding of machine intelligence. The intersection of semantic computing and AI has become increasingly significant, offering sophisticated solutions to complex computational problems and enhancing the way machines interpret and interact with human knowledge. This book serves as a valuable resource for researchers, practitioners, and students seeking to understand the evolution and impact of semantic computing and AI.