On an unassuming day Tom wakes up in the morning. He hears a noise coming from the front of his house. His neighbor Frank wrecks his car into the mailbox. Tom goes into the inner city, to find a car pileup. He finds his wife in Midtown. They brush past looters and thugs. They go their parents farm house. Only to find a man named Bill. They find out that there is an infection spreading across the country. People are turning into savage killers. The survivors go across country trying to find the source of the infection. Along the way they come across cast of characters that come together to fight this infection that is plaguing the country.